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Talibov, V. O., Fabini, E., FitzGerald, E. A., Tedesco, D., Cederfeldt, D., Talu, M. J., Rachman, M. M., Mihalic, F., Manoni, E., Naldi, M., Sanese, P., Forte, G., Lepore Signorile, M., Barril, X., Simone, C., Bartolini, M., Dobritzsch, D., Del Rio, A., & Danielson, U. H. (2021). Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. ChemBioChem, 1–13. https://doi.org/10.1002/cbic.202000736

Sanese, P., Fasano, C., Buscemi, G., Bottino, C., Corbetta, S., Fabini, E., Silvestri, V., Valentini, V., Disciglio, V., Forte, G., Lepore Signorile, M., De Marco, K., Bertora, S., Grossi, V., Guven, U., Porta, N., Di Maio, V., Manoni, E., Giannelli, G., … Simone, C. (2020). Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality. IScience, 23(10), 101604. https://doi.org/10.1016/j.isci.2020.101604

Sociali, G., Liessi, N., Grozio, A., Caffa, I., Parenti, M. D., Ravera, S., Tasso, B., Benzi, A., Nencioni, A., Del Rio, A., Robina, I., Millo, E., & Bruzzone, S. (2020). Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules. Molecular Diversity, 24(3), 655–671. https://doi.org/10.1007/s11030-019-09971-2

Fabini, E., Manoni, E., Ferroni, C., Rio, A. Del, & Bartolini, M. (2019). Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: Current trends. Future Medicinal Chemistry, 11(8), 901–921. https://doi.org/10.4155/fmc-2018-0380

Sociali, G., Liessi, N., Grozio, A., Caffa, I., Parenti, M. D., Ravera, S., Tasso, B., Benzi, A., Nencioni, A., Del Rio, A., Robina, I., Millo, E., & Bruzzone, S. (2019). Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules. Molecular Diversity, 0123456789. https://doi.org/10.1007/s11030-019-09971-2

Parenti, M. D., Santoro, A., Del Rio, A., & Franceschi, C. (2019). Literature review in support of adjuvanticity/immunogenicity assessment of proteins. EFSA Supporting Publications, 16(1). https://doi.org/10.2903/sp.efsa.2019.EN-1551

Fabini, E., Talibov, V. O., Mihalic, F., Naldi, M., Bartolini, M., Bertucci, C., Del Rio, A., & Danielson, U. H. (2019). Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 [Research-article]. Biochemistry, 58(35), 3634–3645. https://doi.org/10.1021/acs.biochem.9b00420

Damonte, P., Sociali, G., Parenti, M. D., Soncini, D., Bauer, I., Boero, S., Grozio, A., Holtey, M. von, Piacente, F., Becherini, P., Sanguineti, R., Salis, A., Damonte, G., Cea, M., Murone, M., Poggi, A., Nencioni, A., Del Rio, A., & Bruzzone, S. (2017). SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorganic and Medicinal Chemistry, 25(20), 5849–5858. https://doi.org/10.1016/j.bmc.2017.09.023

Sociali, G., Magnone, M., Ravera, S., Damonte, P., Vigliarolo, T., Von Holtey, M., Vellone, V. G., Millo, E., Caffa, I., Cea, M., Parenti, M. D., Del Rio, A., Murone, M., Mostoslavsky, R., Grozio, A., Nencioni, A., & Bruzzone, S. (2017). Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model. The FASEB Journal, 31(7), 3138–3149. https://doi.org/10.1096/fj.201601294R

Bellissimo, T., Masciarelli, S., Poser, E., Genovese, I., Del Rio, A., Colotti, G., & Fazi, F. (2017). Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation. In Methods in Molecular Biology (Vol. 1517, pp. 211–221). https://doi.org/10.1007/978-1-4939-6563-2_15

Di Matteo, M., Ammazzalorso, A., Andreoli, F., Caffa, I., De Filippis, B., Fantacuzzi, M., Giampietro, L., Maccallini, C., Nencioni, A., Parenti, M. D., Soncini, D., Del Rio, A., & Amoroso, R. (2016). Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors. Bioorganic & Medicinal Chemistry Letters, 26(13), 3192–3194. https://doi.org/10.1016/j.bmcl.2016.04.078

Arienti, C., Zanoni, M., Pignatta, S., Del Rio, A., Carloni, S., Tebaldi, M., Tedaldi, G., & Tesei, A. (2016). Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer. Oncotarget. https://doi.org/10.18632/oncotarget.7575

Del Rio, A., & Varchi, G. (2016). Molecular Design of Compounds Targeting Histone Methyltransferases. In Epi-Informatics, 1st Edition Discovery and Development of Small Molecule Epigenetic Drugs and Probes (pp. 257–272). Academic press Elsevier. https://doi.org/10.1016/B978-0-12-802808-7.00009-5

Sociali, G., Galeno, L., Parenti, M. D., Grozio, A., Bauer, I., Passalacqua, M., Boero, S., Donadini, A., Millo, E., Bellotti, M., Sturla, L., Damonte, P., Puddu, A., Ferroni, C., Varchi, G., Franceschi, C., Ballestrero, A., Poggi, A., Bruzzone, S., … Del Rio, A. (2015). Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. European Journal of Medicinal Chemistry, 102, 530–539. https://doi.org/10.1016/j.ejmech.2015.08.024

Sagnella, A., Zambianchi, M., Durso, M., Posati, T., Del Rio, A., Donnadio, A., Mazzanti, A., Pistone, A., Ruani, G., Zamboni, R., Benfenati, V., & Melucci, M. (2015). APTES mediated modular modification of regenerated silk fibroin in a water solution. RSC Adv., 5(78), 63401–63406. https://doi.org/10.1039/C5RA10016J

Parenti, M. D., Bruzzone, S., Nencioni, A., & Del Rio, A. (2015). Selectivity hot-spots of sirtuin catalytic cores. Mol. BioSyst., 1720. https://doi.org/10.1039/C5MB00205B

Andreoli, F., & Del Rio, A. (2015). Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes. Computational and Structural Biotechnology Journal, 13, 358–365. https://doi.org/10.1016/j.csbj.2015.04.007

Bacalini, M. G., Gentilini, D., Boattini, A., Giampieri, E., Pirazzini, C., Giuliani, C., Fontanesi, E., Scurti, M., Remondini, D., Capri, M., Cocchi, G., Ghezzo, A., Del Rio, A., Luiselli, D., Vitale, G., Mari, D., Castellani, G., Fraga, M., Di Blasio, A. M., … Garagnani, P. (2015). Identification of a DNA methylation signature in blood cells from persons with Down Syndrome. Aging, 7(2), 82–96. http://www.ncbi.nlm.nih.gov/pubmed/25701644

Bacalini, M. G., Boattini, A., Gentilini, D., Giampieri, E., Pirazzini, C., Giuliani, C., Fontanesi, E., Remondini, D., Capri, M., Del Rio, A., Luiselli, D., Vitale, G., Mari, D., Castellani, G., Di Blasio, A. M., Salvioli, S., Franceschi, C., & Garagnani, P. (2015). A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data. Aging, 7(2), 97–109. http://www.ncbi.nlm.nih.gov/pubmed/25701668

Peserico, A., Germani, A., Sanese, P., Barbosa, A. J., Di Virgilio, V., Fittipaldi, R., Fabini, E., Bertucci, C., Varchi, G., Moyer, M. P., Caretti, G., Del Rio, A., & Simone, C. (2015). A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth. Journal of Cellular Physiology, 230(10), 2447–2460. https://doi.org/10.1002/jcp.24975

Iansante, V., Choy, P. M., Fung, S. W., Liu, Y., Chai, J.-G., Dyson, J., Del Rio, A., D’Santos, C., Williams, R., Chokshi, S., Anders, R. a, Bubici, C., & Papa, S. (2015). PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. Nature Communications, 6, 7882. https://doi.org/10.1038/ncomms8882